The idea is that you treat data storage and data processing as two distinct tasks. You have your data in S3 or HDFS or a local directory and you run DuckDB on whatever single-node compute you have: a local machine or a container in a cluster.

There are companies that write cluster computing engines with duckdb as the byte-cruncher at their heart, but usually it's more like NumPy, Pandas or Polars on steroids. Or SQLite, but for running OLAP queries.