Yeah, that's one of the reasons I waited for usage data is that I was pretty sure people with hEDS would have an overly strong reaction, and that did happen in my case and appears to have happened with other with hEDS. I started at 0.025mg (1/20th the 0.5mg starting dose at the time) and still got temporary gastroparesis which was indeed very uncomfortable. I had done long term fasting prior to semaglutide so I had to just stop eating for a long time while the effects started to wear off. Over the first year I ramped up linearly to 1mg and I've been at that dose since.
Thanks, highly recommended. I forgot to answer, I don’t have MCAS but I do get PEM which I do believe is another form of allergic reaction. I do like to eat histamine inducing foods and I wonder if has kept MCAS desensitized.
I discovered I had PEM this year from working out. Found a trainer that is teaching me to stay in a non hyper mobile range + pacing and that is generally more manageable.
Good luck with the GLP-1. Hit me up via email if you’d like to chat more: HN username at gmail.
