If it helps I played AC Odyssey w/o issues using Proton GE, the biggest issue for me was that when I launched the game through steam, steam would launch the Ubisoft launcher which then launched the game , so I had to manually close this launcher to prevent having proton running in the bg for too long

It's been a while since I gamed though (2022), but the game ran smoothly on a mobile RTX 2060 card