That's more than 600 years. That counts as a long time in my book.

It's basically infinitesimal in comparison to almost everything else we eat or drink.

(Also, an unknown point in the 15th century could be less than 600 years ago.)

How long have we been eating Twinkies

Going by the ingredients list:

sugar, wheat, barley, egg, soybean oil, starch, whey, salt, tallow

These go back before the beginning of history. Quite a long time before.

There are also quite a few additives and preservatives in a Twinkie.† If you're making a point about ultraprocessed food, you're definitely correct. If you're trying to make a point about basic foodstuffs, you aren't.

† https://www.youtube.com/watch?v=KcS3kQg5blw

Ultra processed over a very (relatively) short timeframe

I've read about Dandelion coffee being drank long before then in England.