Yes, which is what I mentioned in the rest of the post. You could distribute a container that has wine in it, with just the configuration necessary to get the software working in the container. It would be straightforward to write a thin abstraction layer that pulls the container (installation) and gives you an executable that you can double click on and launch.

An end user wouldn't need to modify configs or wrestle settings, because that's already done for you upstream. You just get an artifact that you can click and run. From the other posts, Proton and Steam Deck already do something similar, and this is also conceptually similar to the way AppImages, Flatpaks etc. work.