With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.
> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.
So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.
> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight.
It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you...
It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS.
"So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.
Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss?
In other words, would a thin, metabolically healthy person benefit from taking semaglutide?
So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.
> In other words, would a thin, metabolically healthy person benefit from taking semaglutide?
That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.
There's also the intriguing possibility that many other diseases and even addictions have a heretofore-unknown metabolic component. The idea of some addictions -- even to things like heroin or gambling -- being partially metabolic does not seem far-fetched to me.
GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1).
Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get.
This is what happens when you start out with "[thing] is bad" then work backwards to figure out a reason.
Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize.
Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market.
Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people.
Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)
I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places.
Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
I mean it's literally as if people don't understand how drugs work, or what drugs actually do to human bodies.
It is as if those who do not remember the past are repeating it, already.
So many shills are singing the praises of this wonder drug.
In India we're all the rave
Discovered that it's great as aftershave, oh-ho
Dropped in the sea just off Japan
Swapped twenty bottles for an aqua-walkman, oh
Immunity from ridicule
Improves your brains if you're a fool, oh-ho
And I read in the Middle East
Traded some for a hostage release
Now if you're bald it'll give you hair
If you've got straight trousers it'll give you flares
Feeling up you'll get depressed
Out of style here's a brand new dress, oh
It was really vile weather
When we got tarred and feathered
You could hear the six-guns sound
As they chased us out of town
