Yes it will, I have an Amiga 1200 with a Blizzard 1230IV accelerator board. They were super common back in the day. Its 68030 runs at a whopping 50MHz, so you pretty much have to wear a seatbelt.
I had a Blizzard myself, and I kind of remember it was equipped with a 68EC030, that is a 68030 without MMU. And I suspect the reason Serena requires a 68030 is in fact its MMU.