If you haven't yet, check out https://devenv.sh (super powered nix shell and more). It's pretty nice for python packages and installs your requirements to a project local venv for you via whatever tool you want (pip, poetry, uv etc).
I've been using it for a couple of years and it's super nice to be able to manage both python and "native" dependencies, and other non-python development tools all together.
I used just nix and whatever python packages are already in nixpkgs for several projects. And that works really really well until you run into an issue with compatibility like I did. It seems to mostly happen when some extremely common tool like `awscli2` depends on a specific version of some package and so it's pinned.
I've been using it for a couple of years and it's super nice to be able to manage both python and "native" dependencies, and other non-python development tools all together.
I used just nix and whatever python packages are already in nixpkgs for several projects. And that works really really well until you run into an issue with compatibility like I did. It seems to mostly happen when some extremely common tool like `awscli2` depends on a specific version of some package and so it's pinned.