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I suspect https://www.isomorphiclabs.com/ is the reason.

There are 3 basic ways to fund research.

- Taxes - most academic research

- begging - research charities

- profits - companies like Google.

Sometimes the lines get blurred - but I don't think you can expect Google to release as much of their work for free as people who are paid via central taxes.



Worth noting that they did release the AlphaFold 2 weights after a while. Milking an expensive discovery for a limited period should be considered laudable, unless you think tax funding of all research would be awesome and it's just a weird anomaly how the org producing these results was a tiny heterodox startup very recently.


> Worth noting that they did release the AlphaFold 2 weights after a while.

Yes - though I don't think Isomorphic labs existed at that point.

Obviously the real reason AlphaFold was possible was the huge tax payer funded effort running over decades to generate a diverse, high quality 3D structure dataset.

However that's why we put taxes into research - to spur innovation in a pre-competitive way - so that's fine.

What's not fine is any benefiting company avoiding paying any tax back on resulting profits - that's just free riding - and many of the big tech companies are, in my view, guilty.


You know I can appreciate that. For some reason because it’s related to medicine, it feels insidious to keep it closed.


The data is a treasure. It was just as available to others, before and after.


Yep not knocking alphafold - Alphafold showed it could be done[1], and others have subsequently followed.

However if all the tech companies hoover up all the profits and simultaneously avoid paying the appropriate level of taxes - then the cycle of innovation isn't sustainable. As well taxes paying for that pre-competitive data, they train the next generation of PhDs.

[1] There were other groups making progress with DL based structure prediction before Alphafold, but alphafold was a leap forward.




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