The more important point was that medications that do work still come in two forms: ones where we have a good idea of the mechanism of action that makes them work, and ones where we don't.
For example, we have a good idea of why certain antibiotics cure tuberculosis - we understand that tuberculosis is caused by certain bacteria, and we know how antibiotics affect the cellular chemistry of those bacteria to kill them. We also understand the dynamics of this, the fact that the body's immune system still has to be functioning well enough to kill many of the bacteria as well, etc. We don't fully understand all of the side-effects and possible interactions with other diseases or medications in every part of the body, but we understand the gist of it all.
Then there are drugs and diseases where we barely understand any of it. We don't have for example a clear understanding of what depression is, what the biochemistry of it is. We do know several classes of drugs that help with depression in certain individuals, but we know those drugs don't help with other individuals, and we have no way of predicting which is which. We know some of the biochemical effects of these drugs, but since we don't understand the underlying cause of depression, we don't actually know why the drugs help, or what's the difference in individuals where they don't help.
There are also widely used medications where we understand even less. Metamizole, a very widely used painkiller sold as Novalgin or Analgin and other names, discovered in 1922, has no firmly established mechanism of action.
For example, we have a good idea of why certain antibiotics cure tuberculosis - we understand that tuberculosis is caused by certain bacteria, and we know how antibiotics affect the cellular chemistry of those bacteria to kill them. We also understand the dynamics of this, the fact that the body's immune system still has to be functioning well enough to kill many of the bacteria as well, etc. We don't fully understand all of the side-effects and possible interactions with other diseases or medications in every part of the body, but we understand the gist of it all.
Then there are drugs and diseases where we barely understand any of it. We don't have for example a clear understanding of what depression is, what the biochemistry of it is. We do know several classes of drugs that help with depression in certain individuals, but we know those drugs don't help with other individuals, and we have no way of predicting which is which. We know some of the biochemical effects of these drugs, but since we don't understand the underlying cause of depression, we don't actually know why the drugs help, or what's the difference in individuals where they don't help.
There are also widely used medications where we understand even less. Metamizole, a very widely used painkiller sold as Novalgin or Analgin and other names, discovered in 1922, has no firmly established mechanism of action.