Figured people can Google, all I bring is awareness this is widely overblown, having taken myself, for therapeutic purposes, upwards of 100k IU per day for months without doctor supervision (but doing it correctly, with a very low calcium diet). People take vit D megadoses for autoimmunity, with significant success, but I'm not discussing this here.
Since you seem to be an expert: What about different forms of vit D? I vaguely remember discussions about pills not being absorbed well. Also I remember people talking that vit D intervention fails to do anything besides raising the blood levels, indicating that things might be more complex. I'm interested in the topic, but never really dived into it.
There are only two forms, the plant/mushroom form (D2) and animal (D3) form.
As with anything fat-soluble it's wise to take it as part of a meal that includes plenty of fat.
The problem with most studies is, surely in part because of this unfounded fear, they are underdosed. I don't have anything on hand, but I know there are clinics supervising megadose vitamin D protocols all over the world, but mostly in Germany and Latin America, that I'm aware of.
It really means complete elimination or drastic reduction in anything high in calcium, even water can have quite a bit. But this was, again, with extremely high doses. I don't currently follow the protocol, as I do other things, but I sometimes take high doses for a few days.
When I had my first major flare-up, I tested at 7ng/dl (near bottom half of the severe deficiency range). That's what lead me to pay attention to this subject.
>People take vit D megadoses for autoimmunity, with significant success,
You mean for compensating for the low vit D levels due to constant inflammation seen in autoimmunity? or to decrease autoimmunity? I have autoimmune diseases and my vit D goes down to about 7 ng/mL without supplementation, so I'm curious.
That's the same level I had when I got very ill, it's near the bottom half of the insufficiency range, you should definitely consider supplementing and monitoring it.
Per your question, the latter, the theory is autoimmunity is exacerbated in a certain genetic makeup, and to compensate for it by megadosing.
This is one case report. Yes, this person took an insane amount of Vitamin D and ended up very sick from it. But we can't really conclude that amounts under her dose are safe.
Figured people can Google, all I bring is awareness this is widely overblown, having taken myself, for therapeutic purposes, upwards of 100k IU per day for months without doctor supervision (but doing it correctly, with a very low calcium diet). People take vit D megadoses for autoimmunity, with significant success, but I'm not discussing this here.