Probably. I did more than 20Mm (20k km) so far on my mechanical 105 in 2 years and had to replace a single rear shifter cable in between. Mechanical transmissions are not exactly high maintainance either, and maintaince is fairly trivial. Probably would have spent more time charging batteries in 2 years with DI2 than with cable fixes and adjustments on mechanical. But I'm still somewhat intrigued to try it.
Di2 is amazing. If you do > 500km riding a year it's a worthwhile upgrade IMO.