NJ EMT here and the guidance we are given is to not run AED while driving as the vibrations can make the analyzer misread. There are probably different types of AEDs to account for this

I’m guessing the tradeoff in the air is worth it. Can’t stop to run an AED and if they need a shock it’s because they’re in a potentially fatal rhythym

There also isn't constant vibration while flying (except during turbulence) like there is while driving.