I mean the effects would have been immediate, rather than say “develops cancer in 20 years”. Though I guess the narcolepsy took about a month to develop. I suspect there will be much more monitoring and speed with these vaccines than with the swine flu vaccine.
The mechanism for the narcolepsy was a protein present in the virus itself. So actually getting the flu would have been much worse for those with the genes that made them susceptible.
It doesn’t sound like mRNA vaccines would have this vulnerability. Though I do take your point that it’s possible something like the swine flu narcolepsy event would only be found after the fact. However that would be a pretty small consequence since in this case the flu also would have caused worse narcolepsy.
The mechanism for the narcolepsy was a protein present in the virus itself. So actually getting the flu would have been much worse for those with the genes that made them susceptible.
It doesn’t sound like mRNA vaccines would have this vulnerability. Though I do take your point that it’s possible something like the swine flu narcolepsy event would only be found after the fact. However that would be a pretty small consequence since in this case the flu also would have caused worse narcolepsy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562845/