If you've ever worked with light weight http framework in Python or Ruby, it works exactly the same way.

http://mmcgrana.github.com/2010/03/clojure-web-development-r... http://github.com/cgrand/moustache

There isn't a mature web framework for Clojure yet (for obvious reasons), so there isn't a popular "way". At the moment you have a lot of good libraries and you can put your app together in whatever way seems most sound to you.