Checkout vtiger CRM, its pretty much open source version of sugar CRM. Advantages: Complete CRM is opensource, no hidden paid features, there are wide list of free extensions. Few are paid . community support is also good.

Disadvantages: Not much of good UX. You might need to customize to get better user experience.

I guess HTML5 is on the path of replacing javascript, although its still no way near to javascript but not sure what magic it can do.

If javascript would be next big thing then surely can't reach there without HTML5.