You probably have gut dysbiosis causing inflamation of your gut and inflamation leads to depression like symptoms. This doesn’t mean you have to eat keto all the time, but rather that you should take probiotics to restore your gut flora. This way, you can continue eating a balanced diet without allowing that specific bacteria to become overpopulated. The best for me was using Lactobacyllus subtilis HU-58 alongside low-fodmap diet. The low fodmap diet is a shorter period of 1 month, then it needs to continue with the RENEW diet for 3-6months to 1 year. This whole period needs to be supplimented with hu58.
I had some gut bacteria issues and I think I was helped recently by using oregano oil and/or allicine (extract from garlic). Used both for a week, before had 2x antibiotics for suspected SIBO. I also used VivoMaxx 450 probiotics and sodium butyrate for 3 days so maybe it was it. All of these combined are cheaper than single curation with antibiotics so worth giving a shot in case of issues.
Apparently, this was an existing feature on older macOs-es. I used it a lot, but it has been removed as a default setting like ~8 years ago. But luckily you can still add this shortcut to macOs, this is the first thing I do when I get a fresh install:
1. Go to System Settings -> Keyboard -> Keyboard Shortcuts -> App Shortcuts
2. Click the small (+) button under the shortcuts table.
3. Choose/Type the following values in the modal:
- Application: All Applications
- Menu Title: Zoom
- Keyboard shortcut: Command + Shift + M (My preferred shortcut)
4. Click Save.
5. Voila, now you are able to maximize any window, and pressing it again it goes back to its original size. A cool trick is that now if you hover the green (+) button on the top of any page you will be able to access that shortcut from there as well. It sits just under the "Enter Full Screen" menu option.
Sorry for the bad formatting, apparently I cannot edit my comment on HN anymore.
1. Go to System Settings -> Keyboard -> Keyboard Shortcuts -> App Shortcuts
2. Click the small (+) button under the shortcuts table
3. Choose/Type the following values in the modal:
- Application: All Applications
- Menu Title: Zoom
- Keyboard shortcut: Command + Shift + M (My preferred shortcut)
4. Click Save.
5. Voila, now you are able to maximize any window, and pressing it again it goes back to its original size. A cool trick is that now if you hover the green (+) button on the top of any page you will be able to access that shortcut from there as well. It sits just under the "Enter Full Screen" menu option.
Makes me wish macosxhints was still around. This was precisely what that site was about. I wonder whether there’s a modern day, fastish way to learn all this hidden behavior.
The main problem is with stress + gut issues, it's a downward spiraling feedback loop. Stress causes gut irritation, gut irritation makes you more stressed.
I suggest going to a gastroenterolog, that knows about gut flora restoration. Basically you'll get a Low-FODMAP diet for a month, then RENEW diet for ~1 year, but you will also get a bunch of special probiotics, mostly based on Bacillus Subtilis.
During this time the negative feedback loop is being broken, the gut will have a chance to recover and the symptoms should improve/disappear.
I am slowly finishing this diet and I have to say that apart from a few ups and downs, it helped me tremendously. I have much more energy during the day, less oily skin and hair, smoother skin on my face, and consistent stool.
Many (maybe most?) tinnitus cases develop after some partial hearing loss. The mechanism is not known, but one hypothesis is that the brain is "compensating" for frequencies it never hears anymore.
Hearing is logarithmic, the response is non-linear, ergo you may hear X000Hz but not hear X001Hz, yet hear X002Hz. X003Hz may be easier to hear, yet X004Hz may be more difficult than some. It's not a smooth response.
Take a look at some hearing response graphs to get an idea of how variable it can be across the frequency spectrum.
You may notice that I didn't say it was a universal, inescapable experience for those with tinnitus. The question was why there is any relationship at all between hearing loss and tinnitus, which does hold in a large number of cases.
I suggest you to find a good gastroenterologist who is familiar with gut flora restoration treatments. My dad had this reflux issue for ~10 years, and we are both on a 1 year low fodmap diet combined with probiotics treatment. I have to say this is the best improvement that happened in our lives. I was bloated and had digestion issues from a young age that followed me, but now that is gone. No bloating, and no digestion issues at all. Doc says, the gut new gut flora will get strong within 1 year and then we can resume eating everything.
My granddad was a teacher through his life, going ~20km every day by bike for 40 years, in rain and even in the winter. When he became retired, he started physical work of farming crops, making hay for his cows for the winter. He lived for 92 years, while he was still able to walk around and take care of himself on the basic level. He got also a type 2 diabetes around his 80's, but wasn't prescribed metformin. I strongly believe the physical work in his retirement gave him the strength to be in a good shape in his late years.
Whenever we talk about longevity we cannot not mention David Sinclair, who is a leading researcher in longevity. His recent podcast is the most popular on the topic of longevity.
I love listening to him but the problem is I know calorie restriction and time restricted eating is smart but I love good food more.
People don't just want to live longer. They want to basically do absolutely nothing different than what they do now and also live longer. I wish we at least would frame the problem correctly.
The ultimate "best" outcome would be some sort of intervention that mimics the results of calorie restriction or fasting, but without the sacrifice.
But to get there, we need to study the mechanisms through actual calorie restriction and fasting, both to 1. prove that it works in humans, and 2. figure out why.
It’s worth noting that there has been a lot of controversy around Sinclair and his work.
> Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and serial entrepreneur Andrew Perlman, and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, the company was focused on developing Sinclair's research into activators of sirtuins, work that began in the laboratory of Leonard P. Guarente where Sinclair worked as a post-doc before starting his own lab.
> Sirtris went public in 2007 and was subsequently purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million. GSK paid $22.50/share, when Sirtris's stock was trading at $12/share, down 45% from its highest price of the previous year.
> Studies published in 2009 and early 2010 by scientists from Amgen and Pfizer cast doubt on whether SIRT1 was directly activated by resveratrol and showed that the apparent activity was actually due to a fluorescent reagent used in the experiments.
> GSK/Sirtris terminated development of SRT501 in late 2010. GSK said it was terminating SRT501 due to side effects of nausea, vomiting, and diarrhea it caused, and because the compound's activity wasn't specific to SIRT1, at some doses it actually inhibited SIRT1, and the compound itself wasn't patentable.
> In February 2022, Sinclair raised widespread controversy in the longevity research community by rejecting to communicate in an academic debate in which his resveratrol research was criticized after months of mounting evidence against reseveratrol as a longevity intervention.
It's like only focusing on the Steve Jobs failed products and not his successful ones. David Sinclair isn't at the Jobsian level yet but from everything I've read, listened to and viewed, he certainly has the potential to be there.
I am glad this dude is like 20 years older than me, it gives me a safe buffer to decide if I should hop on his train or not. If he still seems healthy in his 70s it will be very interesting.
It’s metal, because usually the predator’s livers can be really toxic. Humans only eat the liver of vegetarian animals, and eating the liver of a carnivore animal could result in death.
